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Quantitation for in vivo and ex vivo NMR spectroscopy

Rabeson, H.; Ratiney, H.; Fauvelle, F.; Cudalbu, C.; Cavassila, S.; Bernard, A.; Giraudon, P.; Van Ormondt, D.; Graveron-Demilly, D.

J. Optoelectron. Adv. Mater. 9(3):505-511 MAR 2007 [ sfx ] [ pubmed ] Article

Abstract: Quantitation of in vivo H-1 short echo-time Magnetic Resonance Spectroscopy (MRS) signals and High Resolution Magic Angle Spinning (HRMAS) Nuclear Magnetic Resonance (NMR) ex vivo signals is challenging. Signals are often contaminated by a background signal originating mainly from macromolecules and lipids. In this paper, emphasis is on the semi-parametric quantitation algorithm QUEST invoking a measured/simulated metabolite basis-set and handling/estimating the background signal. Several applications of QUEST to H-1 in vivo short echo-time, H-1 ex vivo HRMAS-NMR data, as well as H-1 spectroscopic imaging data of human brain at 1.5 Tesla are demonstrated.

Addresses: Univ Lyon, F-69000 Lyon, France.
Univ Lyon 1, F-69622 Villeurbanne, France.
CNRS, UMR 5012, Lab RMN, MIB,ESCPE, F-69622 Villeurbanne, France.
CRSSA, BCM, RMN, La Tronche, France.
Delft Univ Technol, NL-2600 GA Delft, Netherlands.

Email: danielle.graverono@univ-lyon1.fr

Cited by:Shared Ref.
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